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Methylprednisolone (as sodium succinate)

DOI: 10.1111/b.9781405148962.2010.x


Formulation Method Dilution Rate Comments Compatibility Methylprednisolone (as sodium succinate) Vial 40 mg 125 mg 500 mg 1 g Solu‑Medrone Pfizer t/a Pharmacia (UK) 40 mg vial is supplied with 1 mL W 125 mg vial is supplied with 2 mL W 500 mg vial is supplied with 7.8 mL W 1 g vial is supplied with 15.6 mL W Doses up to 250 mg : IV bolus NPSA risk rating: 4 Reconstitute the vial with the W provided. May be further diluted to a convenient volume with NS or G. If a part vial is used, reconstitute the vial with the volumes suggested under ‘Displacement value’ (see comments) Over at least 5 minutes Infusion-related adverse events : bradycardia, hypotension, hypertension, nausea, vomiting, taste disturbances, muscle pain. Arrhythmia, cardiac arrest and circulatory collapse associated with rapid infusion pH : 7‑8 (reconstituted with W) Flush : NS Sodium content : 0.4 mmol/40 mg vial 0.6 mmol/125 mg vial 2.4 mmol/500 mg vial 4.9 mmol/1 g vial Displacement value : negliglible/40 mg vial 0.1 mL/125 mg vial 0.6 mL/500 mg vial 1.1 mL/1 g vial Add 1.9 mL W to 125 mg vial to obtain 125 mg/2 mL solution Add 9.4 mL W to the 500 mg vial to obtain a 500 mg/10 mL solution Add 18.9 mL to the 1 g vial to obtain a 1 g/20 mL solution Other comments : the infusion rate for cord compression is equivalent to 5.4 mg/kg per hour Methylprednisolone ... log in or subscribe to read full text

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