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DOI: 10.1111/b.9781405148962.2010.x


Formulation Method Dilution Rate Comments Compatibility Oxytocin Ampoule 5 units/1 mL 10 units/1 mL Syntocinon Alliance (UK) After caesarean section, prevention of uterine haemorrhage and incomplete, inevitable or missed abortion : IV bolus NPSA risk rating: 2 Ready diluted May be further diluted to a convenient volume with NS Over 3‑5 minutes For some indications the bolus may be followed by an infusion Infusion-related adverse events : rapid administration may cause hypotension. Also arrhythmias, rash, headache, tachycardia, bradycardia, nausea, vomiting Monitor fetal heart rate continuously. Monitor maternal blood pressure and heart rate hourly pH : 3.7‑4.3 (undiluted) Flush : NS Sodium content : negligible Other comments : for further information refer to the documents ‘ Guideline for the use of Oxytocin in Labour ’ and ‘ Guideline for the Management of Postpartum Haemorrhage and Massive Obstetric Haemorrhage ’ or local hospital guidelines. Doses in use at UCLH may be different to licensed doses Prolonged administration of oxytocin in G may result in water intoxication and hyponatraemia Boluses may be given by IM injection if IV access unavailable (unlicensed route of administration) Compatible fluids : NS, G, GS, H, sodium bicarbonate 1.4% Do not infuse with any other medicines or infusion fluids Induction or enhancement of labour ... log in or subscribe to read full text

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