Full Text

Phytomenadione


DOI: 10.1111/b.9781405148962.2010.x


Extract

Formulation Method Dilution Rate Comments Compatibility Phytomenadione Ampoule 10 mg/1 mL Konakion MM Roche (UK) Konakion MM and Konakion Paediatric contain the same drug solution, but are presented in different volumes to aid dosing Adults and children : IV bolus (preferred method) NPSA risk rating: 2 Withdraw the dose and dilute to 10‑20 mL G See comment (b) Over 3‑5 minutes Infusion-related adverse events : injection site reactions, rarely hypersensitivity reactions pH : 5.3‑6.6 (undiluted, Konakion MM and Konakion MM Paediatric) Osmolality : 80 mOsmol/kg (undiluted, Konakion MM and Konakion MM Paediatric) Flush : G Sodium content : 0.1 mmol/1 mL (Konakion MM), negligible (Konakion MM Paediatric) Other comments : (a) after dilution check the solution in the syringe is clear. Use immediately after preparation and discard any syringe with turbid solution (b) the listed dilutions are outside the manufacturer's recommendations but are standard practice at UCLH. Dilution of the bolus dose facilitates administration over 3‑5 minutes. Dilution of the infusion as recommended avoids the need to remove a volume of solution from an infusion bag (b) Konakion MM Paediatric (2 mg/0.2 mL) is also licensed for oral use Compatible fluids : G Do not infuse with any other medicines or infusion fluids Adults and children : (I) IV infusion NPSA ... log in or subscribe to read full text

Log In

You are not currently logged-in to Blackwell Reference Online

If your institution has a subscription, you can log in here:

 

     Forgotten your password?

Find out how to subscribe.

Your library does not have access to this title. Please contact your librarian to arrange access.


[ access key 0 : accessibility information including access key list ] [ access key 1 : home page ] [ access key 2 : skip navigation ] [ access key 6 : help ] [ access key 9 : contact us ] [ access key 0 : accessibility statement ]

Blackwell Publishing Home Page

Blackwell Reference Online ® is a Blackwell Publishing Inc. registered trademark
Technology partner: Semantico Ltd.

Blackwell Publishing and its licensors hold the copyright in all material held in Blackwell Reference Online. No material may be resold or published elsewhere without Blackwell Publishing's written consent, save as authorised by a licence with Blackwell Publishing or to the extent required by the applicable law.

Back to Top