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DOI: 10.1111/b.9781405148962.2010.x


Formulation Method Dilution Rate Comments Compatibility Phytomenadione Ampoule 10 mg/1 mL Konakion MM Roche (UK) Konakion MM and Konakion Paediatric contain the same drug solution, but are presented in different volumes to aid dosing Adults and children : IV bolus (preferred method) NPSA risk rating: 2 Withdraw the dose and dilute to 10‑20 mL G See comment (b) Over 3‑5 minutes Infusion-related adverse events : injection site reactions, rarely hypersensitivity reactions pH : 5.3‑6.6 (undiluted, Konakion MM and Konakion MM Paediatric) Osmolality : 80 mOsmol/kg (undiluted, Konakion MM and Konakion MM Paediatric) Flush : G Sodium content : 0.1 mmol/1 mL (Konakion MM), negligible (Konakion MM Paediatric) Other comments : (a) after dilution check the solution in the syringe is clear. Use immediately after preparation and discard any syringe with turbid solution (b) the listed dilutions are outside the manufacturer's recommendations but are standard practice at UCLH. Dilution of the bolus dose facilitates administration over 3‑5 minutes. Dilution of the infusion as recommended avoids the need to remove a volume of solution from an infusion bag (b) Konakion MM Paediatric (2 mg/0.2 mL) is also licensed for oral use Compatible fluids : G Do not infuse with any other medicines or infusion fluids Adults and children : (I) IV infusion NPSA ... log in or subscribe to read full text

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