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Tranexamic acid

DOI: 10.1111/b.9781405148962.2010.x


Formulation Method Dilution Rate Comments Compatibility Tranexamic acid Ampoule 500 mg/5 mL Cycklokapron Pfizer t/a Pharmacia (UK) Adults : IV bolus NPSA risk rating: 2 Ready diluted May be further diluted to a convenient volume with NS or G Undiluted solution: maximum rate 1 mL/minute Diluted solutions: maximum rate 100 mg/minute Infusion-related adverse events : dizziness and hypotension after rapid administration. Nausea, vomiting, diarrhoea pH : 6.5‑8 Flush : NS Sodium content : nil Compatible fluids : NS, G, GS Do not infuse with any other medicines or infusion fluids Paediatrics : IV bolus NPSA risk rating: 3 Add dose to 50 mL bag of NS or G Over 10 minutes (C) IV infusion via a volumetric infusion pump or syringe pump NPSA risk rating: 4 Dilute dose in a convenient volume of NS or G Usual rate 25‑50 mg/kg per day • For abbreviations refer to the User guide • Prepare a fresh infusion every 24 hours • All preparations are intended for single use only (excluding multidose vials) • If administering medicines via a Y‑site, consult the monograph of each medicine to ascertain appropriate concentrations for infusion and compatible diluents ... log in or subscribe to read full text

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