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DOI: 10.1111/b.9781405148962.2010.x


Formulation Method Dilution Rate Comments Compatibility Benzylpenicillin This is a penicillin. Check allergy status before administration Vial 600 mg Crystapen Genus (UK) Adults, children and neonates : IV bolus (but see comments) NPSA risk rating: 2 If using a whole vial : add 4‑10 mL W or NS to each vial If using part of a vial : add 3.6 mL W or NS to the vial. This gives a 150 mg/mL solution 600 mg over 2 minutes or 1200 mg over 4 minutes Maximum rate 300 mg/minute Infusion-related adverse events : rash, itching, nausea, hypersensitivity reactions, injection site reaction pH : 5.5‑7.5 (reconstituted in W) Osmolarity : 276 mOsmol/L Flush : NS Sodium content : 1.68 mmol/600 mg vial Displacement value : 0.4 mL/600 mg vial Other comments : in children and neonates, if the dose is greater than 50 mg/kg IV infusion is the preferred method When reconstituting benzylpenicillin many nurses find it easier to dissolve the drug in 2 mL of diluent, withdraw the drug, then further dilute to the final volume Benzylpenicillin 600 mg = benzylpenicillin 1 megaunit (1MU) The following data assume benzylpenicillin is infused into the Y‑site as a 1.2 mg/mL solution. Benzylpenicillin solutions of a lower concentration will also be compatible with these drugs and fluids Compatible fluids : NS, G, GS Y‑site compatible when diluted in G or NS : caffeine ... log in or subscribe to read full text

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