Full Text

Aetiology of acne



Extract

The four major factors involved in the aetiology of acne are: 1 Seborrhoea 2 Comedo formation (comedogenesis) 3 Colonization of the intrafollicular duct with P. acnes 4 Inflammation. The most obvious function of the sebaceous glands is to produce sebum and excess sebum production is a prerequisite for the development of acne [1] . The level of sebum secretion correlates reasonably well with the severity of the acne ( Fig. 42.18 ) [2,3] . Fig. 42.18 Correlation between acne severity and sebum excretion. Sebaceous activity is regulated by androgens of gonadal or adrenal origin [4–6] . Androgen-insensitive subjects lack androgen receptors; they do not produce sebum and do not develop acne [5] . Systemic administration of testosterone and dehydroepiandrosterone (DHEAS) increases the size and secretion of sebaceous glands [6] . These two facts support the essential role of androgens in sebum stimulation. Clinical observations pointing to the importance of androgens in acne include the development of early acne in association with increased levels of DHEAS, a precursor of testosterone. The rise of DHEAS in prepubescent children is associated with an increase in sebum production and development of comedonal acne [7] . Androgens regulate sebaceous gland function through binding to nuclear androgen receptors (ARs) [8] . Immunohistochemistry has demonstrated that sebaceous ... log in or subscribe to read full text

Log In

You are not currently logged-in to Blackwell Reference Online

If your institution has a subscription, you can log in here:

 

     Forgotten your password?

Find out how to subscribe.

Your library does not have access to this title. Please contact your librarian to arrange access.


[ access key 0 : accessibility information including access key list ] [ access key 1 : home page ] [ access key 2 : skip navigation ] [ access key 6 : help ] [ access key 9 : contact us ] [ access key 0 : accessibility statement ]

Blackwell Publishing Home Page

Blackwell Reference Online ® is a Blackwell Publishing Inc. registered trademark
Technology partner: Semantico Ltd.

Blackwell Publishing and its licensors hold the copyright in all material held in Blackwell Reference Online. No material may be resold or published elsewhere without Blackwell Publishing's written consent, save as authorised by a licence with Blackwell Publishing or to the extent required by the applicable law.

Back to Top