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Prevention of skin and facial ageing



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Topical protection is the primary means of prevention of photodamage and should be a part of routine skin care. The first sunscreen was developed in 1928, and combined benzylsalicylate and benzylcinnamate [1] . Details of sunscreens and photoprotection are discussed in Chapter 29 . In order to be effective a sunscreen must be both a UVB and UVA filter or reflector. The concept of sun protection factor (SPF) as an assay for protection is well established [2,3] . The methods of evaluating protection by sunscreens against UVA continue to be debated, but guidelines have been established in the UK using an in vitro UVA assay [4] . Photoprotection and topical treatments should be a key part of any antiageing programme. Tretinoin has been shown to be effective for improvement of both photodamaged and intrinsically aged skin [5] . It is a non-selective retinoic acid that increases epidermal thickness, promotes dermal collagen production and reduces its degradation, and inhibits UV-induced matrix metalloproteinases [6] . Other retinoids shown to produce objective clinical and histological changes include retinal, retinaldehyde and retinyl esters [7] . An important part of any topical retinoid treatment protocol is to control retinoid-induced skin irritancy while maintaining retinoid-induced skin rejuvenation. Choice of frequency of treatment and adequate skin moisturization are ... log in or subscribe to read full text

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